Modeling of Human Dermal Absorption of Octamethylcyclotetrasiloxane (D4) and Decamethylcyclopentasiloxane (D5)
نویسندگان
چکیده
منابع مشابه
Sensitive method for quantification of octamethylcyclotetrasiloxane (D4) and decamethylcyclopentasiloxane (D5) in end-exhaled air by thermal desorption gas chromatography mass spectrometry.
Octamethylcyclotetrasiloxane (D4) and decamethylpentasiloxane (D5) are used as ingredients for personal care products (PCPs). Because of the use of these PCPs, consumers are exposed daily to D4 and D5. A sensitive analytical method was developed for analysis of D4 and D5 in end-exhaled air by thermal desorption gas chromatography mass spectrometry (TD-GC-MS), to determine the internal dose for ...
متن کاملAggregate dermal exposure to cyclic siloxanes in personal care products: implications for risk assessment.
Consumers who use personal care products (PCPs) are internally exposed to some of the organic components present of which some may be detected in exhaled air when eliminated. The aim of this study was the quantitative determination of octamethylcyclotetrasiloxane (D4) and decamethylcyclopentasiloxane (D5) in end-exhaled air to study dermal absorption of substances in PCPs. We exposed the forear...
متن کاملCharacterization of ecological risks from environmental releases of decamethylcyclopentasiloxane (D5).
Decamethylcyclopentasiloxane (D5) is used in personal care products and industrial applications. The authors summarize the risks to the environment from D5 based on multiple lines of evidence and conclude that it presents negligible risk. Laboratory and field studies show that D5 is not toxic to aquatic organisms or benthic invertebrates up to its solubility limit in water or porewater or its s...
متن کاملDevelopment of an integrated multi-species and multi-dose route PBPK model for volatile methyl siloxanes - D4 and D5.
There are currently seven published physiologically based pharmacokinetic (PBPK) models describing aspects of the pharmacokinetics of octamethylcyclotetrasiloxane (D4) and decamethylcyclopentasiloxane (D5) for various exposure routes in rat and human. Each model addressed the biological and physico-chemical properties of D4 and D5 (highly lipophilic coupled with low blood: air partition coeffic...
متن کاملMeasurement of cyclic volatile methylsiloxanes in the aquatic environment 1 using low - density polyethylene passive sampling devices using an in - field 2 calibration study – challenges and guidance 3
14 Cyclic volatile methylsiloxanes (cVMS) are used in personal care products and are 15 hydrophobic, volatile and persistent. Their environmental water concentrations are low and 16 are difficult to detect using conventional sampling methods. This study shows the potential of 17 passive sampling for cVMS. We used low-density polyethylene (LDPE) samplers and in-field 18 calibration methods for o...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2007
ISSN: 1096-6080,1096-0929
DOI: 10.1093/toxsci/kfm174